Non-nonsense nurse Epiphany Johnson is a force to be reckoned with. A full-figured woman who speaks her mind and doesn't mince words, Epiphany is quite intimidating. She is a dedicated nurse who doesn't tolerate anyone giving less than 110%. She will call out doctors and nurses alike, when she feels that they are being less than professional. She has a strong moral compass that was never tested more than when her only son, Stanford, decided to go to work for mob boss, Sonny Corinthos. Epiphany strongly disapproved of her son squandering his education on spying for the mob. Despite her objections to Stan's career choices, Epiphany loved her son fiercely and never stopped trying to convince him to make different choices. Sadly, Epiphany would see her greatest fear realized when, during a phone call with Stan, she heard him killed in a mob-ordered hit. The pain of losing her son in such a violent manner took its toll on Epiphany.

In February 2008, Epiphany suffered a serious heart attack and collapsed in the hospital locker room. She had just received her son's cremated ashes and was clutching them in her hands when they found her. Luckily, the doctors were able to save her life.